Home Chemistry Heterocyclic Building Blocks Isothiazoles Benzo[D]Isothiazole
Arylation: Benzo[d]isothiazole can undergo electrophilic aromatic substitution reactions with aryl halides, leading to the introduction of aryl groups on the benzene ring.
Alkylation: Like arylation, benzo[d]isothiazole can undergo alkylation reactions with alkyl halides or alkylating agents, resulting in the addition of alkyl groups to the benzene ring.
Sulfonation: The benzene ring in benzo[d]isothiazole can be sulfonated by reacting it with concentrated sulfuric acid or other sulfonating agents. This can introduce a sulfonic acid group (SO3H) to the benzene ring.
Reduction: The nitrogen in the isothiazole ring can be reduced to the corresponding amine using reducing agents like LiAlH4 or catalytic hydrogenation.
Oxidation: The nitrogen in the isothiazole ring can be oxidized to the corresponding N-oxide or N,N-dioxide using appropriate oxidizing agents.
Cyclization: Benzo[d]isothiazole can participate in cyclization reactions to form various heterocyclic compounds through intramolecular reactions.
Substitution Reactions: The halogen atoms, if present, can undergo substitution reactions with various nucleophiles to introduce different functional groups.
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6-Bromobenzo[d]isothiazole-3-carboxylic acid
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5-Bromobenzo[d]isothiazole-3-carboxylic acid
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